No. |
Title |
Authors |
Journal |
29 |
The Evolutionary Landscape of Alternative Splicing in Vertebrate Species. |
Barbosa-Morais NL. et al. |
Science. (2012) 338(6114): 1587-93 |
Abstract
How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related to the identity of a species than they are to organ type. Most vertebrate species-specific splicing patterns are cis-directed. However, a subset of pronounced splicing changes are predicted to remodel protein interactions involving trans-acting regulators. These events likely further contributed to the diversification of splicing and other transcriptomic changes that underlie phenotypic differences among vertebrate species.
/Presenter : Sung-gwon Lee
/date : 2016.08.09
/PMID : 23258890